欧盟评估一种由纤维素酶、内切-1，3(4)-β-葡聚糖酶和内切-1，4-β-木聚糖酶组成的食品酶的安全性

 　　  2024年1月8日，欧盟食品安全局就一种由纤维素酶、内切-1，3(4)-β-葡聚糖酶和内切-1，4-β-木聚糖酶组成的食品酶的安全性评价发布意见。 
　　据了解，这种食品酶是由非转基因里氏木霉菌株AR-256生产的，旨在用于九种食品制造过程：加工谷物和其他谷物以生产焙烤产品，非焙烤的谷物基产品，酿造产品，淀粉和面筋部分，蒸馏酒精；加工水果和蔬菜以生产葡萄酒和葡萄酒醋、果汁、果汁以外的水果和蔬菜产品以及葡萄以外的水果蒸馏酒精饮料。
 
　　经过评估，专家小组得出结论，该食品酶在预期的使用条件下不会引起安全问题。部分原文报道如下：
 
　　The food enzyme containing cellulase (EC 3.2.1.4), endo-1,3(4)-β-glucanase (EC 3.2.1.6) and endo-1,4-β-xylanase (EC 3.2.1.8) is produced with the non-genetically modified Trichoderma reesei strain AR-256 by AB-Enzymes GmbH. A safety evaluation of this food enzyme was made previously,* in which EFSA concluded that this food enzyme did not give rise to safety concerns when used in seven food manufacturing processes. Subsequently, the applicant requested to extend its use to include two additional processes. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of nine food manufacturing processes: processing of cereals and other grains for the production of 1) baked products, 2) cereal-based products other than baked, 3) brewed products, 4) starch and gluten fractions, 5) distilled alcohol; processing of fruits and vegetables for the production of 6) wine and wine vinegar, 7) juices, 8) fruit and vegetable products other than juices and 9) fruit-derived distilled alcoholic beverages other than from grape. As the food enzyme–total organic solids (TOS) is removed from or not carried into the final foods in three food manufacturing processes, the dietary exposure to the food enzyme–TOS was estimated only for the remaining six processes. It was up to 4.049 mg TOS/kg body weight (bw) per day in European populations. Using the no observed adverse effect level (NOAEL) reported in the previous opinion (939 mg TOS/kg bw per day), the Panel derived a revised margin of exposure of at least 232. based on the revised exposure calculation and the outcome of the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.