2022年1月13日，欧盟食品安全局就一种环麦芽糊精葡聚糖转移酶（cyclomaltodextrin glucanotransferase）的安全性评价发布意见。
据了解，这种食品酶是由Anoxybacillus caldiproteolyticus菌株St-88生产的，旨在用于糖基化甜菊醇糖苷的生产中。
经过评估，专家小组认为，在预期的使用条件下，不能排除饮食暴露引起过敏和诱发反应的风险，但这种情况发生的可能性很低。根据所提供的数据，专家小组得出结论，该食品酶在预期的使用条件下不会引起安全隐患。部分原文报道如下：
The food enzyme cyclomaltodextrin glucanotransferase ((1→4)-α-d-glucan 4-α-d-[(1→4)-α-d-glucano]-transferase (cyclising), EC 2.4.1.19) is produced with Anoxybacillus caldiproteolyticus strain St-88 by PureCircle USA. It is intended to be used in the manufacture of glycosylated steviol glycosides. Residual amounts of total organic solids are removed by the purification steps applied during the production of the modified steviol glycosides; consequently, dietary exposure was not calculated. For the same reason, toxicological studies other than assessment of allergenicity were not considered necessary. Similarity of the amino acid sequence of the food enzyme to those of known allergens was searched and four matches were found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood is considered to be low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
