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| Description Doxorubicin is an anthracycline that exhibits anticancer chemotherapeutic and anti-parasitic, antimalarial activities. Doxorubicin is a DNA intercalator that inhibits topoisomerase II and is clinically used to treat various cancers; it is part of the CHOP and ABVD chemotherapy regimens. Doxorubicin also promotes histone H2AX eviction from chromatin, limiting DNA repair mechanisms. Additionally, this compound inhibits growth of Plasmodium. |
| Specifications |
| Cas No. | 25316-40-9 | | Product ID | D5794 | | Product Name | Doxorubicin HCl 盐酸阿霉素 | | Chemical Name | (8S-cis)10-[(3-Amino-2,3,6-trideoxy-a-L-lyxo- hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11- trihydroxy-8-(hydroacetyl)-1-methoxy-5,12- naphthacenedione | | Synonym | Adriacin; Adriblastina; Adriamycin; Caelyx | | Formula | C27H29NO11 HCl | | Formula Wt. | 579.99 | | Melting Point | 204oC-205oC(dec.) | | Purity | ≥98 % | | Solubility | Soluble in water, methanol or aq alcohols. Soluble in DMSO to 10 mg/mL. Insoluble in acetone, or chloroform. | | Store Temp | +4oC | | Ship Temp | Ambient | | References | Pang B, Qiao X, Janssen L, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. PMID: 23715267.
Tacar O, Sriamornsak P, Dass CR. Doxorubicin: an updat on anticancer molecular action, toxicity and novel drug delivery systems. J Pharm Pharmacol. 2013 Feb;65(2):157-70. PMID: 23278683.
Gamo FJ, Sanz LM, Vidal J, et al. Thousands of chemical starting points for antimalarial lead identification. Nature. 2010 May 20;465(7296):305-10. PMID: 20485427. | |
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