欧盟评估扩展使用一种环麦芽糊精葡聚糖转移酶的安全性

 　　  2025年2月14日，欧盟食品安全局就一种食品酶环麦芽糊精葡聚糖转移酶（cyclomaltodextrin glucanotransferase）的安全性评价发布意见。　　
　　据了解，这种食品酶是由非转基因热解蛋白无氧芽孢杆菌菌株AE-KCGT生产的，旨在用于6种食品生产过程。
　　
　　经过评估，专家小组得出结论，这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下：
　　
　　The food enzyme cyclomaltodextrin glucanotransferase ((1-4)-α-d-glucan 4-α-d-[(1-4)-α-d-glucano]-transferase; EC 2.4.1.19) is produced with the non-genetically modified Anoxybacillus caldiproteolyticus strain AE-KCGT by Amano Enzyme Inc. A safety evaluation of this food enzyme was made previously, in which EFSA concluded that this food enzyme did not give rise to safety concerns for adolescents, adults and the elderly in two food manufacturing processes. Subsequently, the applicant requested to extend its use to include four additional processes and revised the use levels. In this assessment, EFSA updated the safety evaluation of this food enzyme when used in a total of six food manufacturing processes. Dietary exposure was calculated to be up to 0.025 mg total organic solids (TOS)/kg body weight (bw) per day in European populations. When combined with the no observed adverse effect level previously reported (2246 mg TOS/kg bw per day, the highest dose tested), the Panel derived a margin of exposure of at least 89,840. based on the new data, the revised margin of exposure and the previous evaluation, the Panel concluded that this food enzyme does not give rise to safety concerns under the revised intended conditions of use.