欧盟评估转基因里氏木霉菌株DP-Nyf80生产的氨肽酶Y的安全性

 　　  2025年7月14日，欧盟食品安全局就一种氨肽酶Y（aminopeptidase Y）的安全性评价发布意见。 
　　据了解，这种食品酶是由转基因里氏木霉菌株DP-Nyf80生产的，旨在用于3种食品生产过程。
 
　　经过评估，专家小组认为，在预期的使用条件下，不能排除饮食暴露引起过敏反应的风险。根据所提供的数据，评估小组得出结论，这种食品酶在预期使用条件下不会引起安全问题。部分原文报道如下：
 
　　The food enzyme aminopeptidase Y (EC 3.4.11.15) is produced with the genetically modified Trichoderma reesei strain DP-Nyf80 by Genencor International B.V. The genetic modifications do not give rise to safety concerns. Recombinant DNA was not detected under standard testing conditions. However, the absence of viable cells could not be excluded. The food enzyme is intended to be used in three food manufacturing processes. Dietary exposure was calculated to be up to 1.861 mg total organic solids (TOS)/kg body weight per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel identified a no observed adverse effect level of 1000 mg TOS/kg bw per day, the highest dose tested, which when compared with the estimated dietary exposure, results in a margin of exposure of at least 537. A search for the homology of the amino acid sequence of the aminopeptidase Y to known allergens was made and no match was found. The Panel considered that a risk of allergic reactions upon dietary exposure to the food enzyme cannot be excluded, but that the likelihood is low. based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.