食品伙伴网报道，根据美国营养成分网8月17日消息，ω-3脂肪酸的EPA和DHA对血液中血小板凝集所产生的影响大小也有鲜明的性别之分。
这是由来自澳大利亚纽卡斯尔大学的研究者得到的结论，该研究发表在Nutrition, metabolism and Cardiovascular Diseases上。研究表明EPA和DHA可能是由于与性激素的相互作用从而使它们对男性和女性血液中的血小板聚集的影响具有差异。
研究者称，从实验中可得出ω-3脂肪酸的EPA对男性更有益，而DHA则更适合于女性。
研究者对30名健康受试者进行了试验，给他们服下了EPA或DHA中的一种，并在24小时内做出评估，研究发现无论EPA还是DHA都能渠道降低血小板聚集的作用，但是当对受试者进行性别分类时就会发现，相对于EPA,DHA对女性更有利，而EPA则对男性更有利。
原文报道：
New study suggests gender-specific omega-3 roles
By Nathan Gray, 17-Aug-2010
The omenga-3 fatty acids EPA and DHA may have gender-specific effects on blood platelet aggregation, researchers in Australia have found.
The study, published in Nutrition, metabolism and Cardiovascular Diseases, suggests that differences in how males and females process eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) could affect platelet aggregation – due to interactions with sex hormones.
“The distinctive gender-specific, inhibitory response pattern observed in our study suggests that males may benefit more from EPA supplementation while females are more responsive to DHA,” wrote the researchers, led by Monohar Garg from the University of Newcastle in Australia.
The results may have implications for how omega-3’s are formulated in certain supplements.
Clot development
Platelets are mainly responsible for blood clot development and wound healing, but are also involved in the processes of thrombus formation and blood vessel blockage.
There has been a growing demand for the use of non-medical anti-platelet agents, focusing in particular on supplementation with omega-3 polyunsaturated fatty acids like EPA and DHA.
Previous research has shown omega-3 to have a protective role over thrombotic events; although it remains unclear which forms of omega-3 are the most advantageous.
The majority of studies on omega-3 supplements use fish oil containing both EPA and DHA, however recent research has suggested that EPA and DHA have different – gender specific – roles.
Gender bias
The aim of the new study was to establish whether previously observed gender biases effect platelet aggregation.
Thirty healthy participants were given a single dose of either EPA or DHA rich oil, and assessed over 24 hours.
The study saw that both EPA and DHA fatty acids reduced platelet aggregation, but when the data was separated into gender groups the responses were divided according to the suggestions of previous research.
EPA was seen to be highly effective in males when compared to DHA and placebo, whereas in females it was DHA that was found to be significantly more effective than EPA and placebo.
“We have shown that gender-specific responses exist in platelet aggregation in the 24 h following dietary supplementation with a single oral dose of EPA or DHA rich oil capsules. - These data confirm our previous observations..,” stated the researchers.
Changing delivery
The researchers put forward that the observed gender differences may be down to interactions between EPA/DHA and sex hormones.
“Interactions between sex hormones and omega-3 fatty acids exist to differentially reduce platelet aggregation. For healthy individuals, males may benefit more from EPA supplementation while females are more responsive to DHA,” wrote the researchers
The findings of the study could see a change in how omega-3’s are delivered in dietary supplements.
原文地址：http://www.nutraingredients-usa.com/On-your-radar/Omega-3/New-study-suggests-gender-specific-omega-3-roles
日期：2010-08-19